Higher Education on Buildings: Case Study in the North Dakota Region

Because of the growing demand for local skilled professionals to improve the health, energy efficiency, and sustainability of residential and commercial buildings in North Dakota, this case study reports the current situation of higher education relating to buildings in the state’s vicinity, including Minnesota, Montana, North Dakota, and South Dakota. In this region, 116 programs relating to buildings were found in 41 postsecondary institutions, and both their majors and courses were then studied with frequency lists. The frequency information was analyzed over nine sets of curriculum areas at both graduate and undergraduate levels for the four states. After the current state of buildings in North Dakota was investigated, strategies were then proposed to rectify current issues regarding higher education on buildings, including but not limited to forming a comprehensive and interdisciplinary program on buildings (e.g., architectural engineering), providing more graduate programs, developing more courses in areas that lack adequate coursework, and increasing student enrollment. These strategies will greatly promote the health, energy efficiency, and sustainability for new and existing buildings in the four-state region of Minnesota, Montana, North Dakota, and South Dakota

Ultrafast and Ultralight Network-Based Intelligent System for Real-time Diagnosis of Ear diseases in Any Devices

Traditional ear disease diagnosis heavily depends on experienced specialists and specialized equipment, frequently resulting in misdiagnoses, treatment delays, and financial burdens for some patients. Utilizing deep learning models for efficient ear disease diagnosis has proven effective and affordable. However, existing research overlooked model inference speed and parameter size required for deployment. To tackle these challenges, we constructed a large-scale dataset comprising eight ear disease categories and normal ear canal samples from two hospitals. Inspired by ShuffleNetV2, we developed Best-EarNet, an ultrafast and ultralight network enabling real-time ear disease diagnosis. Best-EarNet incorporates the novel Local-Global Spatial Feature Fusion Module which can capture global and local spatial information simultaneously and guide the network to focus on crucial regions within feature maps at various levels, mitigating low accuracy issues. Moreover, our network uses multiple auxiliary classification heads for efficient parameter optimization. With 0.77M parameters, Best-EarNet achieves an average frames per second of 80 on CPU. Employing transfer learning and five-fold cross-validation with 22,581 images from Hospital-1, the model achieves an impressive 95.23% accuracy. External testing on 1,652 images from Hospital-2 validates its performance, yielding 92.14% accuracy. Compared to state-of-the-art networks, Best-EarNet establishes a new state-of-the-art (SOTA) in practical applications. Most importantly, we developed an intelligent diagnosis system called Ear Keeper, which can be deployed on common electronic devices. By manipulating a compact electronic otoscope, users can perform comprehensive scanning and diagnosis of the ear canal using real-time video. This study provides a novel paradigm for ear endoscopy and other medical endoscopic image recognition applications.Comment: This manuscript has been submitted to Neural Network

The α1‐adrenergic receptor is involved in hepcidin upregulation induced by adrenaline and norepinephrine via the STAT3 pathway

Elevated body iron stores are associated with hypertension progression, while hypertension is associated with elevated plasma catecholamine levels in patients. However, there is a gap in our understanding of the connection between catecholamines and iron regulation. Hepcidin is a key iron‐regulatory hormone, which maintains body iron balance. In the present study, we investigated the effects of adrenaline (AD) and norepinephrine (NE) on hepatic hepcidin regulation. Mice were treated with AD, NE, phenylephrine (PE, α1‐adrenergic receptor agonist), prazosin (PZ, α1‐adrenergic receptor antagonist), and/or propranolol (Pro, β‐adrenergic receptor antagonist). The levels of hepcidin, as well as signal transducer and activator of transcription 3 (STAT3), ferroportin 1 (FPN1), and ferritin‐light (Ft‐L) protein in the liver or spleen, were assessed. Six hours after AD, NE, or PE treatment, hepatic hepcidin mRNA levels increased. Pretreatment with PZ, but not Pro, abolished the effects of AD or NE on STAT3 phosphorylation and hepatic hepcidin expression. When mice were treated with AD or NE continuously for 7 days, an increase in hepatic hepcidin mRNA levels and serum hepcidin concentration was also observed. Meanwhile, the expected downstream effects of elevated hepcidin, namely decreased FPN1 expression and increased Ft‐L protein and non‐heme iron concentrations in the spleen, were observed after the continuous AD or NE treatments. Taken together, we found that AD or NE increase hepatic hepcidin expression via the α1‐adrenergic receptor and STAT3 pathways in mice. The elevated hepatic hepcidin decreased FPN1 levels in the spleen, likely causing the increased iron accumulation in the spleen

HI content of massive red spiral galaxies observed by FAST

A sample of 279 massive red spirals was selected optically by Guo et al. (2020), among which 166 galaxies have been observed by the ALFALFA survey. In this work, we observe HI content of the rest 113 massive red spiral galaxies using the Five-hundred-meter Aperture Spherical radio Telescope (FAST). 75 of the 113 galaxies have HI detection with a signal-to-noise ratio (S/N) greater than 4.7. Compared with the red spirals in the same sample that have been observed by the ALFALFA survey, galaxies observed by FAST have on average a higher S/N, and reach to a lower HI mass. To investigate why many red spirals contain a significant amount of HI mass, we check color profiles of the massive red spirals using images observed by the DESI Legacy Imaging Surveys. We find that galaxies with HI detection have bluer outer disks than the galaxies without HI detection, for both ALFALFA and FAST samples. For galaxies with HI detection, there exists a clear correlation between galaxy HI mass and g-r color at outer radius: galaxies with higher HI masses have bluer outer disks. The results indicate that optically selected massive red spirals are not fully quenched, and the HI gas observed in many of the galaxies may exist in their outer blue disks.Comment: 11 pages, 9 figures, accepted by MNRAS; Table 1 is available in the source file

Prevalence and Characterization of Staphylococcus aureus Isolated From Women and Children in Guangzhou, China

The prevalent Staphylococcus aureus clones and antibiotic susceptibility profiles are known to change dynamically and geographically; however, recent S. aureus strains causing infections in women and children in China have not been characterized. In this study, we analyzed the molecular epidemiology and antimicrobial resistance of S. aureus isolated from patients in four centers for women and children in Guangzhou, China. In total, 131 S. aureus isolates (100 from children and 31 from women) were analyzed by spa typing, multi-locus sequence typing, virulence gene and antimicrobial resistance profiling, staphylococcal chromosomal cassette mec typing, and mutation analyses of rpoB. A total of 58 spa types, 27 sequence types (STs), and 10 clonal complexes (CCs) were identified. While CC59 (ST59-IV, 48.8%; ST338-III, 35.7%) and CC45 (ST45-IV, 100%) were the major clones (84.4%) among MRSA isolates, CC5 (ST188, 24.3%; ST1, 21.6%) and CC398 (ST398, 70%) were the major ones (70.1%) among MSSA isolates. ST338-MRSA-III mostly found in pus but hardly in respiratory tract samples while ST45-MRSA-IV was on the opposite, even though they both found in blood and cerebrospinal fluid sample frequently. Staphylococcal enterotoxin genes seb-seq-sek were strongly associated with ST59 and ST338, while sec was associated with ST45, ST121, ST22, and ST30. All ST338, ST1232, and SCCmec III isolates carried lukF/S-PV genes. A total of 80% of ST338 isolates were resistant to erythromycin, clindamycin, and tetracycline. All ST45 isolates exhibited intermediate or complete resistance to rifampicin. In total, 481 HIS/ASN mutations in rpoB were found in rifampicin-resistant or intermediate-resistant isolates. ST338-III and ST45-IV emerged as two of three major clones in MRSA isolates from women and children in Guangzhou, China, though ST59-MRSA-IV remained the most prevalent MRSA clone. Clonal distribution of S. aureus varied, depending on the specimen source. Virulence genes and antibiograms were closely associated with the clonal lineage. These results clarified the molecular epidemiology of S. aureus from women and children in Guangzhou, China, and provide critical information for the control and treatment of S. aureus infections

Propagative Exfoliation of High Quality Graphene

通讯作者地址: Deng, SL (通讯作者) Xiamen Univ, Dept Chem, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China. [email protected]; [email protected] quality graphene materials that readily disperse in water or organic solvents are needed to achieve some of the most ambitious applications. However, current synthetic approaches are typically limited by irreversible structural damages, little solubility, or low scalability. Here, we describe a fundamental study of graphene chemistry and covalent functionalization patterns on sp(2) carbon lattices, from which a facile, scalable synthesis of high quality graphene sheets was developed. Graphite materials were efficiently exfoliated by reductive, propagative alkylation. The exfoliated, propagatively alkylated graphene sheets (PAGenes) not only exhibited high solubility in common solvents such as chloroform, water, and N-methyl-pyrrolidone, but also showed electrical conductivity as high as 4.1 X 10(3) S/m, which is 5 orders of magnitude greater than those of graphene oxides. Bright blue photoluminescence, unattainable in graphene, was also observed. We attribute the rise of blue photoluminescence in PAGenes to small on-graphene sp(2) domains created by the propagative covalent chemistry, which may expand from graphene edges or existing defect sites leaving sp(2)-hybridized patches interlaced with sp(3)-hybridized regions. The intact sp(2) domains enable effective electrical percolation among different graphene layers affording the observed high electrical conductivity in PAGene films.National Key Basic Research Program of China 2013CB933901 National Natural Science Foundation of China 21171140 21021061 21031004 U1205111 Natural Science Foundation of Fujian Province of China 2013J01056 Fundamental Research Funds for the Central Universities University of Maryland U.S. National Science Foundation CAREER CHE-105551